Statin-Induced Immune-Mediated Necrotizing Myopathy: An Increasingly Recognized Inflammatory Myopathy
نویسندگان
چکیده
منابع مشابه
Statin-Induced Necrotizing Autoimmune Myopathy
A 76-year-old man with a history of two prior strokes complicated by residual mild cognitive impairment, atrial fibrillation, coronary artery disease, diabetes mellitus type 2, congestive heart failure, dyslipidemia, and stage 3 chronic kidney disease was admitted for failure to thrive and functional decline. Two months prior, he had been briefly hospitalized for fatigue and inability to walk. ...
متن کاملImmune-mediated Necrotizing Myopathy With Increased Creatine Phosphokinase and Positive Signal Recognition Particle: A Case Report
Background: Knowledge about Immune-Mediated Necrotizing Myopathy (IMNM) has received significantly attention in recent years. In this study, we report a rare case of IMNM with increased Creatine Phosphokinase (CPK) and positive Signal Recognition Particle (SRP). Clinical Presentation and Intervention: The case was a 67-year-old male patient referred to Firozgar hospital affiliated to the Iran ...
متن کاملIdentifying statin-associated autoimmune necrotizing myopathy.
Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this e...
متن کاملStatin-induced Myopathy
Heart disease (HD) is the number one killer in the United States.(1) In 2006, the direct and indirect costs associated with cardiovascular disease in the United States were estimated at 400 billion dollars.(2) Statin therapy for cholesterol reduction is a mainstay intervention for cardiovascular disease (CVD) as reflected in atorvastatin's status as the number one prescribed medication in the U...
متن کاملCLINICAL REVIEW Statin induced myopathy
Since their introduction for the treatment of hypercholesterolaemia in 1987, the use of statins has grown to over 100 million prescriptions per year. About 1.5-3% of statin users in randomised controlled trials and up to 10-13% of participants enrolled in prospective clinical studies develop myalgia. As a conservative estimate, at least 1.5 million people per year will experience amuscle relate...
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ژورنال
عنوان ژورنال: Cureus
سال: 2020
ISSN: 2168-8184
DOI: 10.7759/cureus.7963